The Philippine Science High School has a core curriculum packed with Science and Mathematics courses which aims to develop the scholar in all disciplines. The curriculum is balanced by Humanities courses which foster the full growth of each student’s character. Scholars experience a common freshman year, with a demanding English and Mathematics curriculum, and exposure to Earth Science and Technology Preparation. 

The Science and Mathematics subjects are generally advanced. Starting in the second year, the students take up Biology, Chemistry and Physics as separate subjects while Computer Science is offered in all year levels. Come junior year, scholars begin to pursue their own research projects through their Science and Technology Research classes. They are also given the freedom to choose an elective class from a wide array of course offerings by the different faculty units.